![]() ![]() If you are just beginning your foray into molecular sequence analysis or an experienced genomicist, I encourage you to explore proprietary software bundles. Although several commercial bioinformatics programs are arguably overpriced and overhyped, many are well designed, sophisticated and, in my opinion, worth the investment. This review highlights some of the currently available and most popular commercial bioinformatics packages, discussing their prices, usability, features and suitability for teaching. Although beautifully designed and powerful, user-friendly bioinformatics packages can be expensive and, as more arrive on the market each year, it can be difficult for researchers, teachers and students to choose the right software for their needs, especially if they do not have a bioinformatics background. Given the importance of molecular sequence data in contemporary life science research, these software suites are becoming an essential component of many labs and classrooms, and as such are frequently designed for non-computer specialists and marketed as one-stop bioinformatics toolkits. ![]() For commercial re-use, please contact ĭownloaded from by guest on August 24, 2015Īdvancements in high-throughput nucleotide sequencing techniques have brought with them state-of-the-art bioinformatics programs and software packages. Best free bioinformatics software clc sequence viewer license#This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. He can be found online at and ß The Author 2014. E-mail: David Roy Smith is an assistant professor of biology at the University of Western Ontario, where he studies genome evolution of eukaryotic microbes. David Roy Smith, University of Western Ontario, London, Ontario N6A 5B7, Canada. For example, the journal article describing the basic local alignment search tool (BLAST), which allows a query nucleotide or amino acid sequence to be compared against a database of sequences, has been cited >50 000 times. Given the breadth and depth of questions that can be addressed with primary biological sequence information, many of these programs have become immensely popular. Not long after scientists started generating molecular sequence information, computer-savvy biologists and biology-savvy computer scientists began developing programs to analyse those data. Īnyone who has ever had something sequenced, such as a genome, transcriptome, gene or PCR product, or used nucleotide or protein sequence data in their research has probably dabbled in bioinformatics. ![]() It is also big business and intimately tied to another burgeoning industry-bioinformatics. NGS is now standard fare in almost all facets of life science research. These irritating emails underscore an important point: massively parallel sequencing has arrived to the masses. And Macrogen, a South Korean sequencing conglomerate, dared me to race the HiSeq ‘Xpressway to the $1000 genome’. Illumina recently provided me with ‘a glimpse into the future of genomics’, just by clicking on their buyer’s guide. Yesterday, for example, Beckman Coulter kindly offered to ‘take the stress out of sequencing’ for only a few thousand dollars. INTRODUCTION Most mornings I wake up to a slew of spam email from biotech companies offering unbeatable bargains on next-generation sequencing (NGS). ![]() Keywords: bioinformatics software CLC bio Geneious genome assembly nucleotide alignment phylogenetics software 700 ^709 Advance Access published on 1 September 2014īuying in to bioinformatics: an introduction to commercial sequence analysis software David Roy Smith Submitted: 25th June 2014 Received (in revised form) : 7th August 2014 ![]()
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